Zaza D. Gomurashvili,Jonathan Macferran Hughes,Jie Da,Huashi Zhang
申请号：
US13843244
公开号：
US09102830B2
申请日:
2013.03.15
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention provides biodegradable, biocompatible bis-(α-amino acyl)-diol-diester-containing poly(ester amide) (PEA) and poly(ester urethane) (PEUR) co-polymer compositions with mechanical properties that can be readily tailored by selection of various combinations and proportions of the building blocks of the co-polymers. The compositions are suitable for use in production of drug-releasing biodegradable particles and implantable surgical devices, such as stents and internal fixation devices. The co-polymer compositions, particles and surgical devices biodegrade in vivo by enzymatic action to release bioactive agents in a controlled manner over time as well as biocompatible breakdown products, including one to multiple different amino acids.
