The invention relates to compounds of Formula I and compositions thereof(see formula I)These compounds are useful in the treatment of disease states mediated by thechemokine,Interleukin-8 (IL-8). A preferred compound of the invention is N-{4-chloro-2-hydroxy-3-[(3S)-3 -piperidinylsulfonyl] phenyl } -N'-(3 -fluoro-2-methylphenyl)urea.