An oral transenterocytotic mucosal adhesion vehicle includes a ghost cell formed from fermented bacterium providing a container for uptake and active transport via a lacteal surface and a nano encapsulated drug particle including a bioactive agent which is encapsulated by a polymeric coating disposed within said ghost cell and surviving first pass liver metabolism, wherein the polymeric coating comprises molecules of an alginate and transmucosal delivery enhancing molecules, wherein the transmucosal delivery enhancing molecules are covalently conjugated to the alginate molecules, wherein the polymeric delivery vehicle is resistant to intestinal degradation and wherein the polymeric delivery vehicle is capable of transmucosal passage across the intestinal mucosa into the lymphatic capillary wherein the polymeric delivery vehicle comprising the alginate molecules and transmucosal delivery enhancing molecules covalently conjugated thereto is degraded to release substantially all of the bioactive agent.
