Ali Salanti,Thor Grundtvig Theander,Mads Daugaard,Morten Nielsen,Madeleine Dahlback,Thomas Mandel Clausen
申请号：
US15285830
公开号：
US09932375B2
申请日:
2016.10.05
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention relates to functional binding fragments comprising the minimal binding fragments of VAR2CSA, to antibodies against such binding fragments of VAR2CSA, nucleic acids encoding such fragments of VAR2CSA as well as methods for their production. The invention further relates to conjugates and fusion proteins of VAR2CSA polypeptides including the minimal binding fragments and their use, in particular in the treatment of conditions associated with expression of chondroitin sulfate A (CSA), such as an inappropriate expression of chondroitin sulfate A (CSA).
