The present invention relates to a composition comprising a Nucant multivalent synthetic compound and a glycosaminoglycan, the admixture of both compounds forming microspheres comprising both compounds, as well as their use for the treatment or prevention of diseases associated with deregulation of proliferation and/or angiogenesis, such as cancer, inflammatory disease, or for promoting wound healing.本発明はヌカント多価合成化合物及びグリコサミノグリカンからなる組成物、両化合物からなる微粒子を形成する両化合物の混合に関連し、同様に癌、炎症性疾患、等の増殖及び血管新生の調節機能の低下に関わる疾患の治療又は予防のための、又は創傷治癒の促進のためのそれらの使用に関連する。