In accordance with some embodiments of the disclosed subject matter, mechanisms (which can, for example, include systems, methods, and media) for directional coordinated reset deep brain stimulation are provided. In some embodiments, a method is provided, comprising: implanting a lead with segmented electrodes into an anatomical structure； selecting a first subset of the electrodes corresponding to the anatomical structure as active electrodes； causing electrical pulses at a first stimulation level to be applied at the active electrodes in a first sequence； causing electrical pulses at a second stimulation level that is lower than the first stimulation level to be applied at the active electrodes in a second sequence during a second time period； and inhibiting electrical pulses from being applied at inactive electrodes during the second time period.
