Curtis J. Henrich,Heidi R. Bokesch,Laura K. Cartner,Richard W. Fuller,Kirk R. Gustafson,Kentaro Takada,James B. McMahon,Susan E. Bates,Robert W. Robey,Suneet Shukla,Suresh V. Ambudkar,Michael C. Dean
申请号：
US13910238
公开号：
US20130274323A1
申请日:
2013.06.05
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Disclosed are methods of enhancing the chemotherapeutic treatment of tumor cells, reducing resistance of a cancer cell to a chemotherapeutic agent, a method of inhibiting ABCG2, Pgp, or MRP1 in a mammal afflicted with cancer, and a method of increasing the bioavailability of an ABCG2 substrate drug in a mammal. The methods comprise administering effective amounts of certain compounds to the mammal, for example, a compound of the formula (I):wherein R1, R2, R3, X1, X2, X3, a, and b are as described herein. Uses of these compounds in the preparation of a medicament are also disclosed. Also disclosed are compounds of formula (II), pharmaceutical compositions comprising such compounds and uses thereof.
