This invention discloses a surface anti-biomolecule agent for an artificially or naturally charged substrate. The anti-biomolecule agent comprises a copolymer employing anchoring blocks or domains to binds sites of the substrate via electrostatic attractive force, and employing zwitterionic blocks or domains extended outwardly to reduce the attachment of biomolecules to the substrate.本發明實施例提供一種用於一人工控制帶電或自然帶電基板表面的抗生物分子表面處理試劑,其包含一共聚物具有錨定嵌段或錨定區域(anchoring blocks or domains)利用靜電吸引力結合該基板表面,以及雙離子性嵌段或雙離子性區域(zwitterionic blocks or domains)向外延伸,以減少生物分子附著於該基板表面。
