МАКАФФЕР Иан Камерон Гарднер (GB),ТАСКО Питер Эрнст (GB),ЖАНФРАНЧЕСКО Сушила (GB),СВИФТ Грэхем Джон (GB)
申请号：
RU2012109600/15
公开号：
RU2012109600A
申请日:
2010.08.16
申请国别(地区):
RU
年份:
2013
代理人:
摘要：
1. A composition for powder inhaler (DPI) containing a solvate of (i) beclomethasone and (ii) heptane. 2. A powder inhaler composition (DPI) according to claim 1, wherein the heptane is n-heptane. A powder inhaler composition (DPI) according to claim 1 or 2, wherein said solvate is in crystalline form. A powder inhaler composition (DPI) according to claim 1, wherein said solvate is obtained by crystallization in the presence of ultrasound. A powder inhaler composition (DPI) according to claim 1, comprising particles with a diameter of 0.5-10 microns. A powder inhaler composition (DPI) according to claim 5, wherein the particle size distribution corresponds to the following range of values: X 0 0.5 μm, X 3 3 μm, and X 5 5 μm. A powder inhaler composition (DPI) according to claim 1, further comprising a beta agonist. A powder inhaler composition (DPI) according to claim 7, wherein said beta agonist is salbutamol, levalbuterol or formoterol. A powder inhaler composition (DPI) according to any one of claims 1 to 8, further comprising a carrier. A powder inhaler composition (DPI) according to claim 9, wherein said carrier is lactose, mannitol, glucose or polyethylene glycol. A method for producing beclomethasone solvate, comprising obtaining a suspension of (i) droplets containing beclomethasone dissolved in a solvent in (ii) heptane, and using ultrasound to treat the droplets to form a solvate. 12. The method of claim 11, wherein said heptane is n-heptane. A method according to claim 11 or 12, comprising drying the solvate particles by spray drying. The method of claim 11 or 12, wherein said solvate is in crystalline form. A method of obtaining a beclomethasone composition for p1. Композиция для порошкового ингалятора (DPI), содержащая сольват (i) беклометазона и (ii) гептан.2. Композиция для порошкового ингалятора (DPI) по п.1, где гептан представляет собой н-гептан.3. Композиция для порошкового ингалятора (DPI) по п.1 или 2, где указанный сольват имеет кристаллическую
