EVOX THERAPEUTICS LTD;OXFORD UNIVERSITY INNOVATION
发明人:
HEAN, JUSTIN,MAGER, IMRE,WOOD, MATTHEW,EL ANDALOUSSI, SAMIR,WIKLANDER, OSCAR,NORDIN, JOEL
申请号：
CA3024020
公开号：
CA3024020A1
申请日:
2017.05.25
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
The present invention pertains to an inventive release mechanism for extracellular vesicle (EV)-mediated intracellular and intramembrane delivery of therapeutic polypeptides. More specifically, the invention relates to EVs comprising polypeptide constructs which comprise a therapeutic polypeptide releasably attached to an exosomal polypeptide. Furthermore, the present invention pertains to manufacturing methods, pharmaceutical compositions, medical uses and applications, and various other embodiments related to the inventive EVs.
