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SHORT-CHAIN PEPTIDES AS PARATHYROID HORMONE (PTH) RECEPTOR AGONIST
专利权人:
CADILA HEALTHCARE LIMITED
发明人:
BAHEKAR RAJESH H,JAIN MUKUL R,PATEL PANKAJ R
申请号:
ZA201107078
公开号:
ZA201107078B
申请日:
2011.09.28
申请国别(地区):
ZA
年份:
2014
代理人:
摘要:
The present invention provides novel short-chain peptides, which primarily act as parathyroid hormone (PTH/PTH-1) receptor agonist. These short-chain peptides exhibit increased stability to proteolytic cleavage. Most of short-chain peptides were found to be stable in rat plasma up to 24 hours (in vitro), showed increased stability against GIT enzymes such as pepsin and acidic stomach pH and also against liver microsomes (in vitro). Due to increased metabolic stability, other than parenteral route of administration, some of the short-chain peptides can also be delivered by oral routes of administration, for the treatment/prevention of hypoparathyroidism and diseases characterized by bone mass reduction, such as osteoporosis, postmenopausal osteoporosis and for stimulating bone repair. A-Z1-Z2-Z3-Z4-Z5-Z6-Z7-Z8-Z9-Z10-Z11-Z12-Z13-Z14-Z15-B
来源网站:
中国工程科技知识中心
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http://www.ckcest.cn/home/

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