LIANG, Linda,FAYADAT-DILMAN, Laurence,MALEFYT, Rene De Waal,RAGHUNATHAN, Gopalan
申请号：
AU2020230256
公开号：
AU2020230256A1
申请日:
2020.09.08
申请国别(地区):
AU
年份:
2020
代理人:
摘要：
#$%^&*AU2020230256A120201001.pdf#####ANTI-LAG3 ANTIBODIES AND ANTIGEN-BINDING FRAGMENTS ABSTRACT The present invention includes antibodies and antigen-binding fragments thereof that specifically bind to human or cynomolgous monkey LAG3 as well as immunoglobulin chains 5 thereof and polynucleotides encoding the same along with injection devices comprising such antibodies or fragments. Vaccines includingsuch antibodies and fragments as well as compositions comprising the antibodies and fragments (e.g., including anti-PD Iantibodies) are included in the invention. Methods for treating or preventing cancer or infection using such compositions are also provided. In addition, methods for recombinant expression of the 0 antibodies and fragments are part of the present invention.
