Bernd Jandeleit,Wolf-Nicolas Fischer,Kerry J. Koller,Gordon Ringold
申请号：
US15233566
公开号：
US20160346240A1
申请日:
2016.08.10
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Compositions and methods for protecting normal, healthy cells during chemotherapy are disclosed. The methods include administering one or more compounds that inhibit the cell cycle of rapidly regenerating normal cells and a chemotherapeutic agent. The cell cycle inhibitors can be administered prior to administration of a chemotherapeutic agent. The chemotherapeutic agents can be β-substituted β-amino acids, β-substituted β-amino acid derivatives, and β-substituted β-amino acid analogs. Pharmaceutical compositions comprising the β-substituted β-amino acid derivatives and β-substituted β-amino acid analogs and uses thereof are also disclosed. The β-substituted β-amino acid derivatives and β-substituted β-amino acid analogs can be administered in conjunction with one or more compounds that inhibit the cell cycle of rapidly proliferating normal healthy cells. The cell cycle inhibitors can ameliorate the adverse effects of the β-substituted β-amino acid derivatives and β-substituted β-amino acid analogs.
