Formula (I): The present invention relates to spiro compounds of formula (I),processes for their preparation, pharmaceutical compositions containingthem as active ingredient, methods for the treatment of disease states such ascancers associated with protein tyrosine kinases, especially epidermal growthfactor (EGF) and vascular endothelial growth factor (VEGF), to their methodof use as medicaments and to their method of use in the manufacture of medicamentsfor use in the production of inhibition of tyrosine kinase reducing effects inwarm-blooded animals such as humans.
