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OXYMÉTAZOLINE POUR LE TRAITEMENT DES MALADIES ANO-RECTALES
专利权人:
RDD PHARMA LTD.;BARAK, Nir;RICE, Howard Lawrence
发明人:
BARAK, Nir,RICE, Howard Lawrence
申请号:
ILIL2012/050148
公开号:
WO2012/147084A3
申请日:
2012.04.24
申请国别(地区):
IL
年份:
2014
代理人:
摘要:
The present invention provides methods for treating fecal incontinence by administering to a subject in need thereof compositions comprising oxymetazoline as an active ingredient. The present invention further provides kits comprising compositions of oxymetazoline suitable for topical application, for the treatment of fecal incontinence. The present invention is based in part on the unexpected increase In resting anal pressure obtained upon local administration of relatively low concentrations of oxymetazloine. Surprisingly, the inventors of the present invention have found that unlike other a adrenergic agonists, specifically, pheynilephnne, which either have a short term effect or does not exhibit a pronounced effect on a resting anal pressure, local administration of oxymetazoline provides a long term pronounced increase of the resting anal pressure.La présente invention concerne des méthodes de traitement de l'incontinence fécale qui consistent à administrer à un sujet nécessitant un tel traitement, des compositions comprenant de l'oxymétazoline en tant qu'ingrédient actif. La présente invention concerne également des trousses comprenant des compositions d'oxymétazoline appropriées à l'application topique, pour le traitement de l'incontinence fécale.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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