DEVRIES PETER J,GREEN LARRY L,OSTROW DAVID H,REILLY EDWARD B,WIELER JAMES
申请号：
ZA201004902
公开号：
ZA201004902B
申请日:
2010.07.12
申请国别(地区):
ZA
年份:
2012
代理人:
摘要：
This Hair Ming Department Off Yu Knot He And Ji Huo Red blood cells generate Su Shou Body Kang Body and its Kang Body segments. This Hair Ming Yi Off whats close object using The Kang Body and containing The Kang Body Medical Drug Group, in the method that lactation Move Wu Zhong Tone Festival Red blood cells generate the Inner source activities of element. The present invention relates to antibodies and antibody fragments thereof that bind to and activate an erythropoietin receptor. The present invention also relates to methods of modulating the endogenous activity of an erythropoietin receptor in a mammal using said antibodies as well as pharmaceutical compositions containing said antibodies.[Chong Zuo Te Dot]This Hair of , Ming Department Off Yu With Ren Class Red blood cells in example, which are applied, in a Ge Ju Body Real generates Su Shou Body Knot conjunctions Kang Body. Applied in example in Ge tools Body Real, the anti-Body of The include weight Chain can Change District, Department Election from sequence the 3rd, 7,11,15,19,31,35,39,43,47,51,55 No. and its segment institute Group at group. Applied in example in another Ge tools Body Real, the anti-Body packets of The include Light Chain can Change District, Department Election from sequence the 5th, 9,13,17,21,23,25,27,29,33,37,41,45,49,53,57 No. and its segment institute Group at group. This Hair of , Ming Department Off Yu The Over Fen From Kang Body in example are applied in another Ge Ju Body Real, energy Enough generates Su Shou Body Knot in lactation Move Wu Zhong With Ren Class Red blood cells and closes. 這 Class Kang Body include weight Chain Ke Change District Huo Light Chain Ke Change District comprising From CDR1 to CDR3 Even Continued sequences. The Amino acid sequence , Department Election of heavy Chain Ke Change District including From CDR1 to CDR3 Zhi Even Continued sequences are certainly:The 58th No. of sequence, the 59th No. of sequence, the 60th No. of sequence, sequence the 61st No.
