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5-HT2A receptor modulators and piperazine D3
专利权人:
エフ.ホフマン-ラ;アーゲー;ロシュ;エフ.ホフマン-ラ ロシュ アーゲー
发明人:
ゴッビ,ルカ,ヤーシュケ,ゲオルク,ロドリゲス・サルミエント,ロサ・マリア,スチュワード,ルシンダ,ゴッビ,ルカ,ヤーシュケ,ゲオルク,ロドリゲス・サルミエント,ロサ・マリア,スチュワード,ルシンダ
申请号:
JP2011527297
公开号:
JP5367824B2
申请日:
2009.09.11
申请国别(地区):
JP
年份:
2013
代理人:
摘要:
The present invention provides compounds of the general formula (I) wherein X, n and R1 are as described herein, as well as pharmaceutically acceptable salts and esters thereof, methods for their manufacture, pharmaceutical compositions containing them and their use as medicaments. The active compounds of the present invention are dual modulators of the serotonin 5-HT2a and dopamine D3 receptors, useful in the treatment and/or the prevention of cognitive disorders, drug addiction, depression, anxiety, drug dependence, dementias, memory impairment, psychotic disorders comprising schizophrenia, schizoaffective disorders, bipolar disease, mania, psychotic depression, and psychoses comprising paranoia and delusions.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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