A method of detecting dyssynchrony between a patient and a pressure support system includes receiving patient flow data relating to a flow of gas provided to the patient by the pressure support system, receiving an I/E state signal representing a respiratory phase of the patient as determined by the pressure support system, and analyzing the patient flow data and the I/E state signal and declaring a dyssynchrony for a breath based on at least one of the patient flow data and the I/E state signal. The method includes determining whether at least one of a number of predetermined criterion is satisfied based on at least one of the patient flow data and the I/E state signal, and declaring the dyssynchrony for the breath if it is determined that at least one of the number of predetermined criterion is satisfied.
