The present invention relates to the field of drug development for acute radiation injury caused by exposure (alpha particles, beta particles, neutrons) to the particle (X-ray, gamma rays) or high-energy electromagnetic waves. To date, no effective agent for improving radiation damage following exposure unexpected to ionizing radiation. A method of treating radiation damage in a subject in need of treatment of radiation injury, the present invention provides the above method comprises administering a derivative or functional analogue thereof or peptide less than 30 amino acids. Furthermore, it provides the use of a derivative or a functional analog thereof or peptides smaller than 30 amino acids for the preparation of a pharmaceutical composition for the treatment of a subject invention is considered as afflicted with or suffering from radiation damage to. In particular, the invention provides an anti-radiation peptide having (DRF) dose reduction factor for acute gamma irradiation of at least 1.10, the radiation dose how much, the DRF is 50 30 whole body irradiation (WBI) after % be tested in test groups of mice treated with the peptide at 72 hours WBI after the (LD50 / 30) or as a result of mortality, and radiation dose how much, 30 days total body irradiation (WBI) after be tested in the control group of mice treated only with medium, the peptide at 72 hours WBI after the (LD50 / 30), and the DRF were treated with the peptide herein or as a result 50% mortality and can be determined by, is calculated by dividing the LD50 / 30 of animals treated with the medium, the LD50 / 30 animals. None [Selection Figure]本発明は、高エネルギー電磁波(X線、ガンマ線)又は粒子(アルファー粒子、ベータ粒子、ニュートロン)への被曝により引き起こされる急性放射線障害に対する薬剤開発の分野に関する。今日までに、電離照射への不測の被曝後に放射線障害を改善するための有効な薬剤はない。本発明は、放射線障害の処置が必要な対象の放射線障害を処置する方法であって、30アミノ酸より小さいペプチド又はその機能的類似体若しくは誘導体を投与することを含む上記方法を提供する。さらに、本発明は、放射線障害を患う又は患っていると考えられる対象の処置のための医薬組成物の製造の為の30アミノ酸より小さいペプチド又はその機能的類似体若しくは誘導体を使用する方法を提供する。特に、本発明は、少なくとも1.10の急性ガンマ照射に対する線量減少係数(DRF)を有する抗放射線ペプチドを
