PROBLEM TO BE SOLVED: To provide a composition used for treatment of hypercholemia.SOLUTION: According to the present invention, there is provided a composition for use in the treatment of hypercholemia comprising non-systemically administering to an individual in need thereof a therapeutically effective amount of the composition comprising an Apical Sodium-dependent Bile Acid Transporter Inhibitor (ASBTI) or a pharmaceutically acceptable salt thereof.SELECTED DRAWING: Figure 3【課題】高胆汁血症の処置で使用される組成物の提供。【解決手段】頂端側ナトリウム依存性胆汁輸送体阻害剤(ASBTI)またはその薬学的に許容可能な塩を含む、高胆汁血症の処置で使用される組成物であって、該処置が、治療上有効な量の組成物を、必要としている個体に非全身的に投与することを含む、組成物。【選択図】図3