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VACINA CONJUGADA COMBINADA CONTRA NEISSERIA MENINGITIDIS
专利权人:
NOVARTIS AG
发明人:
PAOLO COSTANTINO
申请号:
PT10179806
公开号:
PT2277537E
申请日:
2002.06.20
申请国别(地区):
PT
年份:
2015
代理人:
摘要:
Precipitated bacterial capsular polysaccharides can be efficiently re-solubilised using alcohols as solvents. The invention provides a process for purifying a bacterial capsular polysaccharide, comprising the steps of (a) precipitation of said polysaccharide, followed by (b) solubilisation of the precipitated polysaccharide using ethanol. CTAB can be used for step (a). The material obtained, preferably following hydrolysis and sizing, can be conjugated to a carrier protein and formulated as a vaccine. Also, in vaccines comprising saccharides from both serogroups A and C, the invention provides that the ratio (w/w) of MenA saccharide : MenC saccharide is >;1.
来源网站:
中国工程科技知识中心
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http://www.ckcest.cn/home/

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