It is another object to provide a process for the preparation of said specific anti-EGFRvIII monoclonal antibody and the invention relates specific anti-EGFRvIII monoclonal antibody. V H chain of the monoclonal antibodies of the present invention comprises, is characterized by having the amino acid sequence of CDR complementarity determining region CDR is selected from the following group. CDR1 that is represented by 5,: SEQ ID NO CDR2, and represented by the 6: SEQ ID NO CDR3 that is represented by 7: SEQ ID NO. None [Selection Figure]【課題】特異的抗EGFRvIIIモノクローナル抗体、および該特異的抗EGFRvIIIモノクローナル抗体の製造方法を提供することにある。【解決手段】本発明のモノクローナル抗体のVH鎖は、相補性決定領域CDRが以下の群から選ばれるCDRのアミノ酸配列を有することを特徴とする。SEQ ID NO:5で示されるCDR1、SEQ ID NO:6で示されるCDR2、およびSEQ ID NO:7で示されるCDR3。【選択図】なし
