Mutasem RAWAS-QALAJI,Ousama RACHID,Keith John SIMONS,Estelle SIMONS,Enrique NIEVES
申请号：
US15358743
公开号：
US20170071881A1
申请日:
2016.11.22
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The invention provides a composition including epinephrine nanoparticles and methods for therapeutic use of the composition in the treatment of conditions responsive to epinephrine such as a cardiac event or an allergic reaction, particularly anaphylaxis. The epinephrine nanoparticles can be incorporated into orally-disintegrating and fast-disintegrating tablet pharmaceutical formulations and can significantly increase the sublingual bioavailability of epinephrine, and thereby reduce the epinephrine dose required. Additionally, the invention provides methods for fabrication of stabilized epinephrine nanoparticles for use in the described compositions.
