Astrid C. Riegler,Leonardo Jose Borras,Roberto Sommavilla
申请号：
US13655743
公开号：
US20130101586A1
申请日:
2012.10.19
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The invention provides antibodies that bind to multiple antigens, said antibodies having at least two antibody light chain variable domains and two antibody heavy chain variable domains, wherein each light chain variable domain is linked to a heavy chain variable domain to form a VH/VL construct, and wherein at least one of the VH domains comprises a particular amino acid at AHo position 12, 103 and/or 144, and at least one of the VL domains comprises a particular amino acid at AHo position 47 and/or 50. Nucleic acid molecules, vectors and host cells for expression of the recombinant antibodies of the invention, methods for isolating them, and the use of said antibodies in medicine are also disclosed.
