A method of identifying the presence of a suspect region such as a polyp in a body cavity of a subject includes generating successive images of a body cavity of the subject, and comparing the successive images of the body cavity, wherein a suspect region of the body cavity is likely present when the successive images are different in terms of intensity, surroundings, registration, and/or protrusions. Also provided is an apparatus comprising a processor and an endoscope having a camera and one or more illuminators such that the processor is configured to compare the images acquired from the camera and the one or more illuminators to identify the presence of a suspect region such as a polyp.
