A system for use in a vascular procedure includes a guidewire dimensioned to remotely access a neurovascular space, a microcatheter for positioning over the guidewire, an interventional treatment element for passage within the catheter member of the microcatheter, and an outer guide positionable over the catheter member of the microcatheter upon removal of the catheter hub. The microcatheter includes an elongated catheter member and a catheter hub. The catheter member defines a longitudinal axis and has a longitudinal length and with proximal and distal ends. The catheter hub is connected to the proximal end of the catheter member and is dimensioned and adapted to be selectively released from the catheter member. The outer guide is advanceable over the catheter member of the microcatheter after the catheter hub is released from the catheter member to a location proximate the lesion. The interventional treatment element is adapted to perform treatment on the lesion within the vasculature
