THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH
发明人:
申请号：
EP05756678.8
公开号：
EP1763509B1
申请日:
2005.07.01
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
Benzoyl urea derivatives that are alpha helical peptide mimetics that mimic BH3-only proteins, compositions containing them, their conjugation to cell-targeting moieties, and their use in the regulation of cell death are disclosed. The benzoyl urea derivatives are capable of binding to and neutralising pro-survival Bcl-2 proteins. Use of the benzoyl urea derivatives in the treatment and/or prophylaxis of diseases or conditions associated with deregulation of cell death are also disclosed.
