ANALOGUES NON CALCEMIQUES, ANTIPROLIFERATION, ACTIFS AU PLAN TRANSCRIPTIONNEL, RENFERMANT DU SOUFRE DE 1-alpha, 25-DIHYDROXYVITAMINE D3

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专利权人:

JOHNS HOPKINS UNIVERSITY

发明人:

申请号：

EP06020197.7

公开号：

EP1745787B1

申请日:

2000.03.31

申请国别(地区):

EP

年份:

2016

代理人:

摘要：

Novel sulfur-containing analogs of 1±,25-dihydroxyvitamin D 3 are provided. These analogs are synthesized in a convergent manner by joining A-ring and C,D ring fragments. Each analog with 1±,3²-substituent stereochemistry shows a pharmacologically desirable combination of high antiproliferative and high transcriptional activities in vitro and also low calcemic activity in vivo.

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