Wolfgang Teschner,Harald Arno Butterweck,Bernhard Kölbl,Lucia Hofbauer,Hans-Peter Schwarz
申请号：
US13595967
公开号：
US20130058961A1
申请日:
2012.08.27
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention provides methods for reducing the amidolytic and anti-complement activity (ACA) content of an immunoglobulin composition through the use of cation exchange chromatography. In a specific embodiment, the invention provides methods for reducing the Factor XI and/or Factor XIa and/or ACA content of an immunoglobulin composition by collecting the leading portion of a cation exchange eluate. The present invention also provides immunoglobulin composition having reduced levels of amidolytic activity, Factor XI, and/or Factor XIa, and/or ACA content.
