Modulator compounds with drug resistance in epithelial tumor cells

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专利权人:

バイオンシル・エス．アール．エル．;バイオンシル・エス.アール.エル.

发明人:

ラビトラノ、マリアルイサ,グラッシリ、エマニュエラ,ヘリン、クリスティアン

申请号：

JP2009553158

公开号：

JP5832721B2

申请日:

2008.03.14

申请国别(地区):

JP

年份:

2015

代理人:

摘要：

The use of compounds is described which are capable of functionally blocking at least one of the genes chosen from the group composed of EphA1, EphA2, EphA8, EphB2, CSF1R, VEGFR2, RAMP2, RAMP3, CLRN1, MAPK4, PIK3C2A, PIK3CG, GSK3alpha, GSK3beta, IRAK3, DAPK1, JAK1, PIM1, TRB3, BTG1, LATS1, LIMK2, MYLK, PAK1, PAK2, CDC2, BTK, PNRC2, NCOA4, NR2C1, TPR, RBBP8, TRPC7, FXYD1, ERN1, PRSS16, RPS3, CCL23 and SERPINE1, for the manufacture of a medicament destined to diminish the resistance to chemotherapeutic drugs in the therapeutic treatment of epithelial tumour pathologies. Also described is a method for the determination of the drug resistance in tumour cells, as well as a method for the identification of tumour stem cells.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/