ÉVALUATION DE LA GRAVITÉ DES PATIENTS ATTEINTS D'UNE INFECTION À FLAVIVIRUS PAR LES NIVEAUX D'HYALURONANE SANGUIN ET AGENTS THÉRAPEUTIQUES POUR BLOQUER L'HYALURONANE
The present invention discloses a method to determine whether a warning sign will occur in a subject with the Flavivirus infectious illness, and a pharmaceutical composition. The method includes steps of measuring the level of serum hyaluronan of the subject, and determining that the warning sign will occur in his/her illness course when the level is higher than or equal to 70 ng/mL. It is identified in the invention that the level of the serum hyaluronan is an excellent predicator for the severity of the Flavivirus infectious illness. The pharmaceutical composition is used for blocking the serum hyaluronan of the Flavivirus-infected subjects to prevent inflammation, and includes a therapeutically effective amount of a 4-methyl umbelliferone sodium salt, a CD44 siRNA, an anti-CD44 antibody or a hyaluronidase, wherein the therapeutically effective amount is an effective blood concentration of the 4-methyl umbelliferone sodium salt, the CD44 siRNA, the anti-CD44 antibody, and the hyaluronidase of the subject being in a range from 0.05 mM to 5 mM, 1 nM to 100 nM, 5 µg/ml to 500 µg/ml and 0.5 unit/mL to 50 units/mL, respectively.
