Advanced Medical Projects;Centro de Investigación Biomédica en Red (CIBER);Universidad Autónoma de Madrid;Consejo Superior de Investigaciones Cientificas (CSIC)
发明人:
申请号：
EP14856578.1
公开号：
EP3061815A4
申请日:
2014.10.24
申请国别(地区):
EP
年份:
2017
代理人:
摘要：
The invention relates to a polypeptide which comprises the fragment SEQ ID No.: 2 of the peptide GSE 24.2 (SEQ ID No.:1) and can reduce the production of free radicals and/or damage to the DNA structure of a cell, optionally comprising nuclear localisation sequences. The invention also relates to a polynucleotide and to a vector, which comprise sequences coding for said polypeptide, and to a pharmaceutical composition comprising said polypeptide, polynucleotide and/or vector. The invention further relates to the applications of the polypeptide, such as the use thereof for treating and/or preventing diseases caused by an increase in oxidative stress and/or damage to cellular DNA, such as ataxia-telangiectasia or dyskeratosis congenita, or the use thereof in tissue engineering and cell culture for increasing the viability of same.
