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PROTÉINE DE FUSION POUR LIAISON VEGF
专利权人:
Korea Prime Pharm Co.; Ltd.
发明人:
申请号:
EP17167657.0
公开号:
EP3239172B1
申请日:
2017.04.22
申请国别(地区):
EP
年份:
2018
代理人:
摘要:
The present invention relates to a fusion protein binding to a vascular endothelial growth factor (VEGFR). The fusion protein of the present invention comprises (a) a Fc domain of IgG1, wherein two heavy chains are linked by disulfide bond, and (b) four immunoglobulin domain2s of the VEGFR1, wherein two immunoglobulin domain2s are sequentially fused to each heavy chain of the Fc domain of (a). The present fusion protein has excellent activities of inhibiting cell migration and cell invasion, and has highly enhanced growth inhibition effects to various carcinomas and fibroblasts. Therefore, the fusion protein of the present invention can be used in the preparation of an agent for treating cancers or ocular diseases.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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