KROTZSCH GOMEZ, FERNANDO EDGAR,FURUZAWA CARBALLEDA, GUADALUPE JANETTE
申请号：
CA2568409
公开号：
CA2568409C
申请日:
2005.05.25
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
The invention relates to a chronic articular inflammation-modulatingcomposition which uses collagen-polyvinylpyrrolidone. Collagen turnover ismodulated using collagen-PVP in patients with rheumatoid arthritis andosteoarthritis, since the biocomplex negatively regulates collagenolyticactivity and increases the content of type III collagen and TIMP-1 to levelssimilar to those observed in normal synovia. In this way, the chronicinflammatory process is altered by the collagen-PVP, as described above, owingto the negative regulation of IL-1, the TNF- of IL-8 and the adhesionmolecules, since said molecules can induce the expression and activation ofcollagenolytic enzymes, as well as the proliferation and migration of synovialcells by means of the adhesive mechanisms including the adhesion molecules,and the induction and activation of Cox-1. In addition to cellular anchoring,the interaction of the extracellular matrix integrins generates signals whichregulate the expression of MMPs, suggesting that the adhesion molecules canalso play a part in tissue destruction associated with rheumatoid arthritis.Moreover, the decrease in the synthesis of TNF- and IL-1 appears to stimulatethe cell death of synoviocytes by means of apoptosis, which, in turn, seems tocontribute to the inhibition of the proliferation of synovial cells, theformation of pannus and the destruction of the articular tissue.
