A medical tubing set can comprise a fluid conduit adapted to convey a medical fluid； an optical element coupled to the fluid conduit and configured to provide illumination； and a power source configured to power the optical element. A method of operating a medical tubing set, the medical tubing set comprising a fluid conduit adapted to convey a medical fluid, an optical element coupled to the fluid conduit and configured to provide illumination, and a power source configured to power the optical element, can comprise installing the medical tubing set in a medical device at a first end and in a patient at a second end； providing a source of power with the power source； applying the source of power to the optical element； and illuminating the fluid conduit with the optical element.
