Methods for preventing, ameliorating, or reducing dermatological signs of aging are provided which employ active agents that modulate the PLOD-2 enzyme in the skin. Also provided are methods for screening for substances which modulate PLOD-2 enzyme levels and the methods of using active agents identified by the screening protocol in the treatment of skin.本發明提供用於預防、改善或減輕皮膚老化跡象之方法,其使用調節皮膚中之PLOD-2酶的活性劑。亦提供篩選調節PLOD-2酶水準之物質的方法及使用經過篩選法所識別之活性劑來治療皮膚之方法。