TACK, Johannes,WYRWA, Ralf,Laube, Thorsten,SCHNALBELRAUCH, Matthias,WEISSER, Jürgen,VÖLKEL, Christoph
申请号：
DK16719009
公开号：
DK3277660T3
申请日:
2016.03.30
申请国别(地区):
DK
年份:
2020
代理人:
摘要：
The present invention relates to novel compounds of the formula I, methods for their preparation and their use for treatment of diseases. The invention discloses the synthesis of levodopa (L-DOPA) esters by coupling polyhydroxy compounds or their derivatives to the L-DOPA carboxyl group. The synthesis allows to produce L-DOPA derivatives which are highly soluble in water as well as aqueous and biocompatible liquids and have an improved hydrolytic stability in water or aqueous and biocompatible media for an application over several days. The invention helps producing L-DOPA substances for applications in the fields of medicine, biology and medical engineering as well as in the pharmaceutical industry.
