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ORALLY ADMINISTERED MEDICAL COMPOSITION
专利权人:
ASTELLAS PHARMA INC.
发明人:
TSUTSUI YUUKI,TOYOTA HIROYASU,HAKOMORI TADASHI
申请号:
PH12015500313
公开号:
PH12015500313A1
申请日:
2015.02.12
申请国别(地区):
PH
年份:
2015
代理人:
摘要:
In order to provide to clinical practices a single pharmaceutical preparation having a controlled release part including mirabegron or a pharmaceutically acceptable salt thereof and a rapid release part including In order to provide to clinical practices a single pharmaceutical preparation having a controlled release part including mirabegron or a pharmaceutically acceptable salt thereof and a rapid release part including solifenacin or a pharmaceutically acceptable salt thereof: (1) provided is a single pharmaceutical preparation wherein the elution profile of each medication is unchanged from conventional pharmaceutical preparations; and (2) provided is a single pharmaceutical preparation having a maximum medication elution rate of at least 90 pcnt for each medication and exhibiting a similar bioavailability to conventional pharmaceutical preparations. Furthermore, (3) a single pharmaceutical preparation is provided that exhibits good productivity whereby tableting problems are suppressed and exhibits good storage stability whereby coloration of the rapid release part thereof is suppressed. This orally administered medical composition contains (1) a controlled release part including mirabegron or a pharmaceutically acceptable salt thereof and (2) a rapid release part including solifenacin or a pharmaceutically acceptable salt thereof and calcium stearate.
来源网站:
中国工程科技知识中心
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