MURPHY, ANDREW J.,墨菲 安德鲁,墨菲 安德魯,KOSTIC, ANA,科斯蒂克 安娜,墨菲 安德鲁,墨菲 安德魯,科斯蒂克 安娜
申请号：
TW102111629
公开号：
TW201343675A
申请日:
2013.04.01
申请国别(地区):
TW
年份:
2013
代理人:
摘要：
The present invention provides antibodies and antigen-binding fragments thereof that specifically bind HLA-B*27 (also called HLA-B27). In certain embodiments, the antibodies of the invention bind soluble and/or cell surface-expressed forms of HLA-B*27. The antibodies of the present invention, in certain embodiments, inhibit HLA-B*27-mediated activation of T cells. Certain exemplary antibodies of the present invention exhibit enhanced binding to HLA-B*27 as compared to other HLA-B allelic variants (e.g., HLA-B*07). The present invention also provides anti-HLA-B*27 antibodies with pH-dependent binding characteristics (e.g., higher affinity binding at neutral pH than at acidic pH). The antibodies of the invention are useful for the treatment of diseases and disorders associated with HLA-B*27 expression, including ankylosing spondylitis and other spondyloarthropathies.本發明提供特異結合HLA-B*27(亦稱為HLA-B27)之抗體及其抗原-結合片段。在某些具體例中，本發明抗體結合可溶性及/或細胞表面表現形式的HLA-B*27。在某些具體例中，本發明抗體抑制HLA-B*27媒介的T細胞活化。相較於對其他HLA-B對偶基因變體(例如HLA-B*07)，本發明的某些例示性具體例顯示對HLA-B*27的結合提升。本發明亦提供具有pH依賴性結合特性(例如在中性pH下比在酸性pH下的親和力結合力更高)的抗-HLA-B*27抗體。本發明抗體可用於治療與HLA-B*27表現有關的疾病與病症，包括僵直性脊椎炎與其他脊柱關節病變。
