MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
发明人:
Svetomir N. MARKOVIC,Wendy K. NEVALA
申请号：
MX2019002474
公开号：
MX2019002474A
申请日:
2017.08.31
申请国别(地区):
MX
年份:
2019
代理人:
摘要：
Described herein are compositions of binding agents and carrier proteins, and optionally at least one therapeutic agent, and methods of making and using the same, in particular, as a cancer therapeutic. Also described are lyophilized compositions of binding agents and carrier proteins, and optionally at least one therapeutic agent, and methods of making and using the same, in particular, as a cancer therapeutic. Still also described are methods for treating and/or increasing the therapeutic effectiveness of an immunotherapy of a patient suffering from a cancer which expresses PD-L1 or PD-L2 by administering to the patient a nanoparticle composition and a PD-1 immunotherapy.En el presente documento se describen composiciones de agentes de union y proteinas portadoras, y opcionalmente al menos un agente terapeutico, y metodos para fabricar y usar el mismo, en particular, como agente terapeutico contra el cancer； tambien se describen composiciones liofilizadas de agentes de union y proteinas portadoras, y opcionalmente al menos un agente terapeutico, y metodos para hacer y usar el mismo, en particular, como agente terapéutico contra el cancer； tambien se describen metodos para tratar y/o aumentar la eficacia terapeutica de una inmunoterapia de un paciente que padece un cancer que expresa PD-L1 o PD-L2 administrando al paciente una composicion de nanoparticulas y una inmunoterapia con PD-1.
