Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms

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专利权人:

President and Fellows of Harvard College

发明人:

Bitterman, Kevin J.,Sinclair, David A.

申请号：

AU2006212770

公开号：

AU2006212770B2

申请日:

2006.02.08

申请国别(地区):

AU

年份:

2013

代理人:

摘要：

The invention provides methods and compositions for modulating the life span of eukaryotic and prokaryotic cells and for protecting cells against certain stresses, e.g., heatshock. One method comprises modulating the flux of the NAD+ salvage pathway in the cell, e.g., by modulating the level or activity of one or more proteins selected from the group consisting of NPTl, PNCl, NMAl and NMA2. Another method comprises

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