Compounds derived from 2.3 - benzodiazepines replaced intermediaries； Compounds； Pharmaceutical formulation； use for prophylaxis and / or treatment of tumoral Disorders such as Leukemia, Prostate Carcinoma, Breast Carcinoma, melanoma, among others and Control of male fertility.
What is described are BET protein-inhibitory, in particular BRD4-inhibitory 2,3-benzodiazepines of the general formula (I) in which R1a, R1b, R1c, R2, R3, R4, R5, A and X have the meanings given in the description, intermediates for preparing the compounds according to the invention, pharmaceutical compositions comprising the compounds according to the invention and their prophylactic and therapeutic use for hyperproliferative disorders, in particular for tumour disorders. Also described is the use of BET protein inhibitors for benign hyperplasias, atherosclerotic disorders, sepsis, autoimmune disorders, vascular disorders, viral infections, for neurodegenerative disorders, for inflammatory disorders, for atherosclerotic disorders and for the control of male fertility.COMPUESTOS DERIVADOS DE 2,3-BENZODIAZEPINAS SUSTITUIDAS CON FENILO INHIBIDORES DE PROTEÍNA BET； COMPUESTOS INTERMEDIARIOS； COMPOSICIÓN FARMACÉUTICA； USO EN TRASTORNOS HIPER PROLIFERATIVOS, TRASTORNOS TUMORALES, HIPERPLASIA BENIGNA, TRASTORNOS ATEROESCLERÓTICOS, SEPTICEMIA, TRASTORNOS AUTO INMUNES, ENTRE OTROS.
