Systems and methods for discriminating between various gases, e.g., argon and helium, for enhanced safety of medical devices are provided. The present disclosure may take the form of a dedicated-use embodiment where a specific gas, helium for example, is expected, and an enabling or “Go” signal is issued when that gas is detected, or an inhibitory or “No-Go” signal when a gas is present that is not identified as helium. Alternately, a control line or input command can be used to select between helium and argon as the expected gas and then issue the appropriate “Go/No-Go” signal, depending on which gas is identified.