TRAITEMENT DU MYELOME MULTIPLE ET DE LA RESORPTION OSSEUSE PROVOQUEE PAR LE MYELOME AU MOYEN D'ANTAGONISTES DE L'INTERACTION -CAM-1/VLA-4

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专利权人:

THE UNIVERSITY OF TEXAS SYSTEM;BOARD OF REGENTS

发明人:

MUNDY, GREGORY R.,YONEDA, TOSHIYUKI

申请号：

CA2343579

公开号：

CA2343579C

申请日:

1999.09.13

申请国别(地区):

CA

年份:

2012

代理人:

摘要：

Antagonists of alpha4 integrin/alpha4 integrin ligand adhesion, which inhibitthe biological effects of such adhesion are described and methods for theiruse are detailed. Such antagonists are useful in suppressing bone destructionassociated with multiple myeloma. The homing of multiple myeloma cells to bonemarrow and their alpha4 integrin-dependent release of bone-resorbing factors,resulting in bone destruction in patients with multiple myeloma, is inhibited.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/