BETANCORT, Juan Manuel,STAFFORD, Jeffrey Alan,STANSFIELD, Ryan,VEAL, James Marvin
申请号：
PE2017002306
公开号：
PE20180036A1
申请日:
2016.04.22
申请国别(地区):
PE
年份:
2018
代理人:
摘要：
It refers to the synthesis of a drug in the crystal form of 4 - [2 - (cycloacrylonitrile) - 5-methylthionylphenyl] - 2-methylisoquinine-1-ona. In some achievements, drug synthesis includes 4 - [2 - (cyclophilmethyl) - 5-methylthiophenyl] - 2-methylisoquinine-1-ona, which is treated by micro ion or spray drying. In some results, the pharmacological composition includes at least one polymer. In some achievementsThe pharmacological composition includes a matrix of simple matter polygons including 4 - [2 - (cycloacrylonitrile) - 5-methylthiophenyl] - 2-methylisoquinine-1-ona and at least one polymer. This pharmacology composer is an effective tool for treating cancer or tumorReferida a una composicion farmaceutica que comprende la forma cristalina A de 4-[2-(ciclopropilmetoxi)-5-metilsulfonilfenil]-2-metilisoquinolin-1-ona. En algunas realizaciones, la composicion farmaceutica comprende 4-[2-(ciclopropilmetoxi)-5-metilsulfonilfenil]-2-metilisoquinolin-1-ona que se ha procesado por micronizacion o dispersion secada por pulverizacion. En algunas realizaciones, la composicion farmaceutica comprende ademas al menos un polimero. En algunas realizaciones, las composiciones farmaceuticas comprenden una matriz polimerica solida que comprende 4-[2-(ciclopropilmetoxi)-5-metilsulfonilfenil]-2-metilisoquinolin-1-ona y al menos un polimero. Dichas composiciones farmaceuticas son utiles para el tratamiento del cancer o enfermedades neoplasicas
