PROBLEM TO BE SOLVED: To provide a novel compound, as well as a method for manufacturing the same, effective to Parkinson's disease, cognitive impairment, cerebrovascular disease, stroke, congestive heart disease, hypertension, allergic rhinitis, autoimmune and inflammatory diseases, or female sexual dysfunction, etc.SOLUTION: 1- or 2-substituted (6aR,9aS)-3-(phenylamino)-5-6a,7,8,9,9a-hexahydro-5-methyl-cyclopent[4,5]imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4(1H or, 2H)-one compounds, their use as pharmaceuticals and pharmaceutical compositions comprising them are provided.【課題】パーキンソン病、認知障害、脳血管疾患、脳卒中、鬱血性心疾患、高血圧症、アレルギー性鼻炎、自己免疫および炎症疾患、または女性の性機能障害等に有効な新規化合物、およびその製造方法の提供。【解決手段】１－もしくは２－置換（６ａＲ，９ａＳ）－３－（フェニルアミノ）－５－６ａ，７，８，９，９ａ－ヘキサヒドロ－５－メチル－シクロペンタ［４，５］イミダゾ［１，２－ａ］ピラゾロ［４，３－ｅ］ピリミジン－４（１Ｈもしくは２Ｈ）－オン化合物、それらを含む医薬品および医薬組成物としてのその使用。【選択図】なし
