Weixang Dai,James L. Funderburgh,Joel S. Schuman,Nirmala SundarRaj
申请号：
US12321812
公开号：
US08815946B2
申请日:
2009.01.26
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Provided herein are methods of preventing a fibrotic response and/or scarring in a wound, comprising administering to a subject a composition comprising an amount of an amide or ester of an alpha-ketoalkanoic acid effective to inhibit a proliferative and/or fibrotic response in the wound. In one instance, the wound is to a subjects cornea, such as a wound resulting from refractive surgery. In one embodiment, the amide or ester of an alpha-ketoalkanoic acid is ethyl pyruvate.
