Bentley, Michael David,Roberts, Michael James,Shen, Xiaoming,Cheng, Lin
申请号：
HK16103153.9
公开号：
HK1215171A
申请日:
2016.03.17
申请国别(地区):
HK
年份:
2016
代理人:
摘要：
The invention provides polymer conjugates of opioid antagonists comprising at least one polymer backbone, such as poly(ethylene glycol), covalently attached to a residue of an opioid antagonist. The linkage between the polymer and the opioid antagonist is preferably hydrolytically stable. The invention also includes a method of treatment of one or more side effects associated with the use of opioid analgesics, such as constipation, nausea, or pruritus, by administering a polymer conjugate of the invention.
