INHIBITION DE L'ACTIVATION ET DE LA POTENTIALISATION DES LYMPHOCYTES T RÉGULATEURS ENTRAÎNÉES PAR UNE CELLULE DENDRITIQUE DE RÉPONSES DES LYMPHOCYTES T SPÉCIFIQUES D'UN ANTIGÈNE DE TUMEUR PAR L'INTERLEUKINE-15 ET UN INHIBITEUR DE LA KINASE MAP
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS
发明人:
CANNON, MARTIN, J.,KOZAK, KELLIE, J.,O'BRIEN, TIMOTHY, J.,OBRIEN, TIMOTHY, J.
申请号：
EP08834390
公开号：
EP2205252A4
申请日:
2008.09.27
申请国别(地区):
EP
年份:
2012
代理人:
摘要：
The invention involves the discovery that if dendritic cells loaded with a tumor antigen are cultured in interleukin-15 (IL-15), or if T cells activated by the dendritic cells are cultured in IL-15, Treg activity that is specific for the tumor antigen is reduced. This reduction in Treg activity results in an increase in anti-tumor immune response. Another embodiment of the invention involves the discovery that incubating dendritic cells with a MAP kinase inhibitor in combination with IL-15 gives synergistic benefits when the dendritic cells are used to activate T cells. Dendritic cell and T cell compositions incubated with IL-15 or a MAP kinase inhibitor are provided.
