ANDREW DAVID MILLER,PATRICK ARBUTHNOT,MICHAEL JORGENSEN,MICHAEL KELLER,NAZILA KAMALY,ABDERRAHIM AISSAOUI,MAYA THANOU
申请号：
IN4447/DELNP/2009
公开号：
IN2009DN04447A
申请日:
2009.07.06
申请国别(地区):
IN
年份:
2012
代理人:
摘要：
The present invention provides a lipid of the formula (I) R3R4N-[Y]q-(CpH2p)-X-Linker-NR1R2 (I) wherein R3 and R4 are independently selected from H and hydrocarbyl groups q is an integer selected from 1 to 10 Y represents a group (CnH2n)NR5, wherein (i) when q is 1, n is 2, or (ii) when q is greater than 1, each Y may be the same or different and each n is an integer independently selected from 1 to 10, with the proviso that for at least one unit Y, n is 2, and (iii) each R5 is independently selected from H and hydrocarbyl groups p is an integer selected from 1 to 10 X is an optional group selected from -NR7-, -C(=O)-N R8-, -NR9-C(=O)-, -C(=O)-, -O-, and -NR10-C(=0)0-, wherein each R7, R8, R9 and R10 is independently selected from H and hydrocarbyl groups, Linker is an optional group selected from amino acid residues, peptide residues and groups of the formula -(OCH2CH2)1-10, -NR6-(CvH2v)-C(=O)-, wherein R6 is H or a hydrocarbyl group and v is an integer selected from 1 to 11, and -C(=0)-(CH2)0-10-CH2-C(=0)- R1 is selected from acyclic groups having from 4 to 30 carbon atoms and R2 is selected from H and acyclic groups having from 4 to 30 carbon atoms. Said lipids can be used in a delivery vehicle (e.g. micelle or liposome) for the delivery of one or more (therapeutic or diagnostic) agents.
